平衡型核苷转运蛋白1 (hENT1) (平衡型硝基苯甲硫嘌呤核糖苷敏感性核苷转运蛋白) (平衡型NBMPR敏感性核苷转运蛋白) (es核苷转运蛋白) (核苷转运蛋白, es型) (溶质载体家族29成员1)
平衡型核苷转运蛋白1 (hENT1) (平衡型硝基苯甲硫嘌呤核糖苷敏感性核苷转运蛋白) (平衡型NBMPR敏感性核苷转运蛋白) (es核苷转运蛋白) (核苷转运蛋白, es型) (溶质载体家族29成员1)
Q99808功能描述
参与核苷和核碱基易化转运的单向转运蛋白，有助于维持其细胞稳态 (PubMed:10722669, PubMed:10755314, PubMed:12527552, PubMed:14759222, PubMed:15037197, PubMed:17379602, PubMed:21795683, PubMed:26406980, PubMed:27995448, PubMed:35790189, PubMed:8986748)。作为不依赖Na(+)的转运蛋白发挥作用 (PubMed:8986748)。参与腺苷、鸟苷、肌苷、尿苷、胸苷和胞苷等核苷的转运 (PubMed:10722669, PubMed:10755314, PubMed:12527552, PubMed:14759222, PubMed:15037197, PubMed:17379602, PubMed:26406980, PubMed:8986748)。也转运嘌呤核碱基（次黄嘌呤、腺嘌呤、鸟嘌呤）和嘧啶核碱基（胸腺嘧啶、尿嘧啶） (PubMed:21795683, PubMed:27995448)。介导基底外侧核苷摄取进入支持细胞，从而调节睾丸中跨血睾屏障的核苷转运 (By similarity)。调节棕色脂肪组织 (BAT) 中的肌苷水平和细胞外肌苷水平，进而控制依赖BAT的能量消耗 (PubMed:35790189)。 {ECO:0000250|UniProtKB:O54698, ECO:0000269|PubMed:10722669, ECO:0000269|PubMed:10755314, ECO:0000269|PubMed:12527552, ECO:0000269|PubMed:14759222, ECO:0000269|PubMed:15037197, ECO:0000269|PubMed:17379602, ECO:0000269|PubMed:21795683, ECO:0000269|PubMed:23639800, ECO:0000269|PubMed:26406980, ECO:0000269|PubMed:27995448, ECO:0000269|PubMed:35790189, ECO:0000269|PubMed:8986748}.
组织特异性
Expressed in testis at the blood-testis barrier (at protein level) (PubMed:23639800). Detected in erythrocytes (at protein level) (PubMed:11584005, PubMed:23219802). Expressed at relatively high levels in cerebral cortex, particularly the frontal and parietal lobes, and the thalamus and basal ganglia (at protein level) (PubMed:11311901). In the midbrain expressed at moderate levels, whereas in the other areas of the brainstem, namely medulla and pons, cerebellum and the hippocampus expressed at lower amounts when compared to the other brain regions (at protein level) (PubMed:11311901). Expressed in Langerhans cells and lymphocytes in the pancreas (at protein level) (PubMed:15501974). Expressed in kidney, in polarized renal epithelial cells (PubMed:12527552). Expressed in adipose tissues (PubMed:35790189). Expressed in placenta (PubMed:8986748). Expressed in small intestine (PubMed:10755314).
亚细胞定位
Basolateral cell membrane
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