SLC22A3 O75751

溶质载体家族22成员3 (神经元外单胺转运蛋白) (EMT) (有机阳离子转运蛋白3) (OCT3)

功能描述

生电性电压依赖性转运蛋白，介导多种有机阳离子的转运，如内源性生物活性胺、阳离子药物和异生物质 (PubMed:10196521, PubMed:10966924, PubMed:12538837, PubMed:17460754, PubMed:20858707)。阳离子的细胞摄取或释放由电化学势驱动，即膜电位和浓度梯度 (PubMed:10966924)。作为不依赖Na(+)和Cl(-)的双向单转运蛋白发挥作用 (PubMed:12538837)。参与单胺类神经递质的摄取，如多巴胺、肾上腺素、去甲肾上腺素、组胺、5-羟色胺和酪胺，从而支持在大脑中胺能神经传递的稳态调节作用 (PubMed:10196521, PubMed:16581093, PubMed:20858707)。以低效率转运多巴胺能神经调节剂环(组-脯)和salsolinol (PubMed:17460754)。可能参与通过从血流中的肾脏清除来摄取和处置阳离子化合物 (PubMed:10966924)。可能有助于调节睾丸中跨血睾屏障的阳离子化合物转运 (Probable)。介导多胺亚精胺和腐胺的转运 (By similarity)。介导多胺鲱精胺的双向转运 (PubMed:12538837)。也转运胍 (PubMed:10966924)。也可能介导细胞内有机阳离子的转运，从而在胺代谢和细胞内信号传导中发挥作用 (By similarity)。 {ECO:0000250|UniProtKB:O88446, ECO:0000269|PubMed:10196521, ECO:0000269|PubMed:10966924, ECO:0000269|PubMed:12538837, ECO:0000269|PubMed:16581093, ECO:0000269|PubMed:17460754, ECO:0000269|PubMed:20858707, ECO:0000305|PubMed:35307651}。

组织特异性

Expressed in liver (PubMed:10196521, PubMed:9933568). Expressed in intestine (PubMed:16263091, PubMed:20858707). Expressed in kidney in proximal tubular cells (PubMed:10966924). Expressed in placenta (PubMed:10966924, PubMed:9933568). Expressed throughout the brain, including cerebral cortex, cerebrellum, substancia nigra, medulla oblongata, hippocampus, caudate nucleus, nucleus accumbens and pons with low levels of expression detected in nearly all brain regions (PubMed:10196521, PubMed:20858707). In testis, mostly localized to peritubular myoid cells and Leydig cells, and weakly expressed in developing germ cells (PubMed:35307651). Expressed in tracheal and bronchial epithelium of the respiratory tract, where it localizes to the apical membrane of ciliated cells, the entire membrane of basal cells and the basolateral membrane of intermediate cells (PubMed:15817714). Expressed in skeletal muscle, adrenal gland, heart, prostate, aorta, salivary gland, adrenal gland, uterus, lymph node, lung, trachea and spinal cord (PubMed:10196521, PubMed:20858707, PubMed:9933568). Expressed in fetal lung and liver (PubMed:9933568).

亚细胞定位

Cell membrane