SLC22A13 Q9Y226

溶质载体家族22成员13 (有机阴离子转运蛋白10) (OAT10) (有机阳离子转运蛋白样3) (ORCTL-3) (ORCTL3)

功能描述

阴离子反向转运蛋白，介导尿酸盐、乳清酸和烟酸的转运，以交换有机或无机阴离子 (PubMed:18411268, PubMed:31780526, PubMed:35144162, PubMed:35462902)。将尿酸盐和乳清酸转运穿过近端小管上皮细胞的顶端膜，并参与尿酸盐的肾脏重吸收 (PubMed:18411268, PubMed:31780526, PubMed:35144162)。可能参与乳清酸的肾脏重吸收和烟酸的肠道重吸收 (PubMed:18411268, PubMed:35144162)。介导尿酸盐摄取，通过与有机阴离子如 (S)-乳酸、琥珀酸、谷胱甘肽和烟酸进行交换 (PubMed:18411268)。尿酸盐和乳清酸的转运依赖于 Cl(-) (PubMed:35144162, PubMed:35462902)。显示出与尿酸盐/乳清酸肾脏反向转运蛋白 SLC22A12/URAT1 相似的转运特征，并在特定条件下可能作为 SLC22A12/URAT1 的补偿者 (Probable)。 {ECO:0000269|PubMed:18411268, ECO:0000269|PubMed:31780526, ECO:0000269|PubMed:35144162, ECO:0000269|PubMed:35462902, ECO:0000305|PubMed:35144162, ECO:0000305|PubMed:35462902}。

组织特异性

Ubiquitous (PubMed:10072596). Highly expressed in kidneys and to a weaker extent in brain, heart, and intestine (PubMed:18411268). In kidneys, expressed in proximal convoluted tubule (PubMed:18411268, PubMed:31780526, PubMed:35462902). In kidneys, also expressed in cortical collecting duct, whereas glomerulus and thick ascending limb exhibit no expression (PubMed:18411268).

亚细胞定位

Apical cell membrane