SLC22A1 O15245

溶质载体家族22成员1 (有机阳离子转运蛋白1) (hOCT1)

功能描述

生电性电压依赖性转运蛋白，介导多种有机阳离子的转运，如内源性生物活性胺、阳离子药物和异生物质 (PubMed:11388889, PubMed:11408531, PubMed:12439218, PubMed:12719534, PubMed:15389554, PubMed:16263091, PubMed:16272756, PubMed:16581093, PubMed:19536068, PubMed:21128598, PubMed:23680637, PubMed:24961373, PubMed:34040533, PubMed:9187257, PubMed:9260930, PubMed:9655880)。作为不依赖pH和Na(+)的双向转运蛋白发挥作用 (By similarity)。阳离子的细胞摄取或释放由电化学电位（即膜电位和浓度梯度）及底物选择性驱动 (By similarity)。疏水性是多价底物和抑制剂识别的主要要求 (By similarity)。主要表达于肝细胞和近端小管的基底侧膜，通过从血流中的肝和肾清除参与阳离子化合物的摄取和处置 (By similarity)。最可能作为肠细胞中的摄取载体发挥作用，促进有机阳离子从体循环中的肠道消除 (PubMed:16263091)。转运内源性单胺，如N-1-甲基烟酰胺 (NMN)、胍基丁胺、组胺、神经递质多巴胺、血清素和肾上腺素 (PubMed:12439218, PubMed:24961373, PubMed:35469921, PubMed:9260930)。也以低亲和力但相对较高的周转率转运天然多胺，如亚精胺、鲱精胺和腐胺 (PubMed:21128598)。参与肝细胞对维生素B1/硫胺素的摄取，从而调节肝脏脂质和能量代谢 (PubMed:24961373)。介导乙酰胆碱 (ACh) 在气道上皮纤毛细胞顶膜的双向转运，从而在支气管上皮腔内释放ACh中发挥作用 (PubMed:15817714)。以较低的效率转运多巴胺能神经调节剂环(组-脯)和salsolinol (PubMed:17460754)。也能够转运非胺类内源性化合物，如前列腺素E2 (PGE2) 和前列腺素F2-alpha (PGF2-alpha) (PubMed:11907186)。可能有助于睾丸中阳离子化合物跨越血睾屏障的转运 (Probable)。也参与异生物质三丁基甲基铵 (TBuMA)、奎尼丁、N-甲基奎宁 (NMQ)、N-甲基奎尼丁 (NMQD)、N-(4,4-azo-n-pentyl)-quinuclidine (APQ)、azidoprocainamide methoiodide (AMP)、N-(4,4-azo-n-pentyl)-21-deoxyajmalinium (APDA) 和 4-(4-(dimethylamino)styryl)-N-methylpyridinium (ASP) 的摄取 (PubMed:11408531, PubMed:15389554, PubMed:35469921, PubMed:9260930)。 {ECO:0000250|UniProtKB:O08966, ECO:0000250|UniProtKB:Q63089, ECO:0000269|PubMed:11388889, ECO:0000269|PubMed:11408531, ECO:0000269|PubMed:11907186, ECO:0000269|PubMed:12439218, ECO:0000269|PubMed:12719534, ECO:0000269|PubMed:15389554, ECO:0000269|PubMed:15817714, ECO:0000269|PubMed:16263091, ECO:0000269|PubMed:16272756, ECO:0000269|PubMed:16581093, ECO:0000269|PubMed:17460754, ECO:0000269|PubMed:19536068, ECO:0000269|PubMed:21128598, ECO:0000269|PubMed:23680637, ECO:0000269|PubMed:24961373, ECO:0000269|PubMed:34040533, ECO:0000269|PubMed:35469921, ECO:0000269|PubMed:9187257, ECO:0000269|PubMed:9260930, ECO:0000269|PubMed:9655880, ECO:0000305|PubMed:35307651}.; FUNCTION: [Isoform 1]: 介导1-甲基-4-苯基吡啶 (MPP(+)) 的摄取。 {ECO:0000269|PubMed:11388889}.; FUNCTION: [Isoform 2]: 不能摄取1-甲基-4-苯基吡啶 (MPP(+))。 {ECO:0000269|PubMed:11388889}.; FUNCTION: [Isoform 3]: 不能摄取1-甲基-4-苯基吡啶 (MPP(+))。 {ECO:0000269|PubMed:11388889}.; FUNCTION: [Isoform 4]: 不能摄取1-甲基-4-苯基吡啶 (MPP(+))。 {ECO:0000269|PubMed:11388889}.

组织特异性

Widely expressed with high level in liver (PubMed:11388889, PubMed:23680637, PubMed:9187257, PubMed:9260930). In liver, expressed around the central vein (PubMed:16263091). Expressed in kidney (PubMed:9187257, PubMed:9260930). Expressed in small intestine enterocytes (PubMed:16263091, PubMed:23680637). Localized to peritubular myoid cells, Leydig cells and moderately to the basal membrane of Sertoli cells in testes (PubMed:35307651). Expressed in tracheal and bronchial ciliated epithelium in the respiratory tract (PubMed:15817714). Also expressed in skeletal muscle, stomach, spleen, heart, placentacolon, brain, granulycytes and lymphocytes (PubMed:9187257, PubMed:9260930).

亚细胞定位

Basolateral cell membrane