SLC17A3 O00476

钠依赖性磷酸盐转运蛋白 4 (Na(+)/PI协同转运蛋白 4) (NPT4) (钠/磷酸盐协同转运蛋白 4) (溶质载体家族17成员3)

功能描述

介导尿毒症毒素3-硫酸吲哚酚的肾脏排泄。 {ECO:0000250|UniProtKB:Q5SZ93}.; FUNCTION: [Isoform 2]: 以电压驱动、多特异性的方式在肾近端小管顶侧转运有机阴离子 (PubMed:20810651)。特别是，参与将尿酸从细胞分泌到管腔中 (PubMed:20810651)。尿酸是嘌呤代谢的终产物 (PubMed:20810651)。可能在硫酸雌酮、雌二醇-17-β-葡萄糖醛酸苷、赭曲霉毒素A以及药物如布美他尼的代谢和分泌中起作用 (PubMed:20810651)。 {ECO:0000269|PubMed:20810651, ECO:0000303|PubMed:20810651}.

组织特异性

Expressed in the liver and kidney (PubMed:20810651, PubMed:9149941). It is detected in proximal tubules in renal cortex as well as some tubules and glomeruli, with highest expression at the apical side of proximal tubules (at protein level) (PubMed:20810651).

亚细胞定位

[Isoform 1]: Endoplasmic reticulum membrane