SIRPG Q9P1W8

信号调节蛋白γ (SIRP-gamma) (CD172抗原样家族成员B) (信号调节蛋白beta-2) (SIRP-b2) (SIRP-beta-2) (CD抗原CD172g)

功能描述

可能的免疫球蛋白样细胞表面受体。与CD47结合后，介导细胞-细胞粘附。T细胞上的该受体与抗原呈递细胞上的CD47结合，导致抗原特异性T细胞增殖增强并共刺激T细胞活化。 {ECO:0000269|PubMed:15383453}。

组织特异性

Detected in liver, and at very low levels in brain, heart, lung, pancreas, kidney, placenta and skeletal muscle. Expressed on CD4+ T-cells, CD8+ T-cells, CD56-bright natural killer (NK) cells, CD20+ cells, and all activated NK cells. Mainly present in the paracortical T-cell area of lymph nodes, with only sparse positive cells in the mantle and in the germinal center of B-cell follicles. In the thymus, primarily expressed in the medulla on mature T-lymphocytes that have undergone thymic selection.

亚细胞定位

Membrane