SIGLEC5 O15389

唾液酸结合Ig样凝集素 5 (Siglec-5) (CD33抗原样2) (肥胖结合蛋白 2) (OB-BP2) (OB结合蛋白 2) (CD抗原 CD170)

功能描述

推定的粘附分子，介导依赖唾液酸的细胞结合。与α-2,3-连接和α-2,6-连接的唾液酸同等结合。唾液酸识别位点可能被与同一细胞表面上的唾液酸的顺式相互作用所遮蔽。

组织特异性

Expressed by monocytic/myeloid lineage cells. Found at high levels in peripheral blood leukocytes, spleen, bone marrow and at lower levels in lymph node, lung, appendix, placenta, pancreas and thymus. Expressed by monocytes and neutrophils but absent from leukemic cell lines representing early stages of myelomonocytic differentiation.

亚细胞定位

Membrane; Single-pass type I membrane protein.