SIGLEC10 Q96LC7

唾液酸结合Ig样凝集素10 (Siglec-10) (Siglec样蛋白2)

功能描述

推定的粘附分子，介导依赖唾液酸的细胞结合。优先结合α-2,3-或α-2,6-连接的唾液酸 (By similarity)。唾液酸识别位点可能被与同一细胞表面唾液酸的顺式相互作用所遮蔽。在免疫应答中，似乎作为抑制性受体起作用，在配体诱导的酪氨酸磷酸化后，通过其SH2结构域招募细胞质磷酸酶，通过信号分子的去磷酸化阻断信号转导 (PubMed:11284738, PubMed:12163025)。参与B细胞抗原受体信号转导的负调控。B细胞激活的抑制依赖于PTPN6/SHP-1 (By similarity)。与CD24结合可能参与选择性抑制对危险相关分子模式 (DAMPs) 的免疫应答，如HMGB1、HSP70和HSP90 (By similarity)。与CD24结合可能调节自然杀伤 (NK) 细胞的免疫应答 (PubMed:25450598)。在自身免疫控制中发挥作用 (By similarity)。在CD8-alpha(+)树突状细胞启动适应性免疫应答期间，通过损害MHC I类分子-肽复合物的形成抑制交叉呈递。该功能似乎涉及招募PTPN6/SHP-1，其使NADPH氧化酶复合物的NCF1去磷酸化，从而促进吞噬体酸化 (By similarity)。 {ECO:0000250|UniProtKB:Q80ZE3, ECO:0000269|PubMed:11284738, ECO:0000269|PubMed:25450598, ECO:0000305|PubMed:12163025}。

组织特异性

Expressed by peripheral blood leukocytes (eosinophils, monocytes and a natural killer cell subpopulation). Isoform 5 is found to be the most abundant isoform. Found in lymph node, lung, ovary and appendix. Isoform 1 is found at high levels and isoform 2 at lower levels in bone marrow, spleen and spinal cord. Isoform 2 is also found in brain. Isoform 4 is specifically found in natural killer cells.

亚细胞定位

[Isoform 1]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 3]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 4]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 5]: Secreted.