SHOX O15266

矮小同源盒蛋白 (假常染色体含同源盒成骨蛋白) (含矮小同源盒蛋白)

功能描述

控制生长基本方面的转录因子。在成骨细胞中直接激活NPPB转录 (PubMed:11751690, PubMed:17881654)。优先结合序列为5'-TAATNNNATTA-3'的DNA元件，可能以同源二聚体形式 (PubMed:11751690)。 {ECO:0000269|PubMed:11751690, ECO:0000269|PubMed:17881654}。

组织特异性

Expressed at high levels in bone marrow fibroblasts and trabecular bone cells (PubMed:9259282). Also detected in placenta (PubMed:9259282). Expressed in bone growth plate, with high levels in the zone of hypertrophic chondrocytes and lower expression in proliferating and resting chondrocytes (at protein level) (PubMed:17881654). in the knee cartilage, tends to be expressed at higher levels in men, compared to women (PubMed:38580675).

亚细胞定位

Nucleus