SHC4 Q6S5L8

SHC转化蛋白4 (Rai样蛋白) (RaLP) (SHC转化蛋白D) (hShcD) (含Src同源2结构域转化蛋白C4) (SH2结构域蛋白C4)

功能描述

激活黑色素瘤中依赖于Ras和不依赖于Ras的迁移通路。参与agrin诱导的CHRNB1酪氨酸磷酸化的早期阶段。 {ECO:0000269|PubMed:17409413}。

组织特异性

Only expressed in melanomas. Weakly expressed in normal melanocytes and benign nevi. Highly expressed at the transition from radial growth phase to vertical growth phase and metastatic melanomas, when tumor cells acquire migratory competence and invasive potential.

亚细胞定位

Postsynaptic cell membrane. Note=Colocalized with MUSK at the neuromuscular junction.