丝氨酸蛋白酶抑制剂B6 (胞质抗蛋白酶) (CAP) (肽酶抑制剂6) (PI-6) (胎盘凝血酶抑制剂)
丝氨酸蛋白酶抑制剂B6 (胞质抗蛋白酶) (CAP) (肽酶抑制剂6) (PI-6) (胎盘凝血酶抑制剂)
P35237功能描述
可能参与调节脑内存在或从血液渗出的丝氨酸蛋白水解酶（根据相似性）。组织蛋白酶G、激肽释放酶-8和凝血酶的抑制剂。可能在内耳发挥重要作用，在应激期间防止溶酶体内容物渗漏，失去这种保护会导致细胞死亡和感音神经性听力损失。 {ECO:0000250, ECO:0000269|PubMed:10068683, ECO:0000269|PubMed:17761692, ECO:0000269|PubMed:20451170, ECO:0000269|PubMed:8136380, ECO:0000269|PubMed:8415716}。
组织特异性
Expressed in keratinocytes (at protein level). Highest levels in skeletal muscle. Also found in placenta, cardiac muscle, lung, liver, kidney and pancreas. Expressed in the inner ear hair cells. Expressed abundantly by normal mast cells in different tissues and by mast cells in mastocytoma lesions.
亚细胞定位
Cytoplasm
关键词