SERF1A O75920

富含EDRK的小因子1 (蛋白4F5) (h4F5) (SMA修饰因子1)

功能描述

淀粉样蛋白聚集和蛋白毒性的正调节因子 (PubMed:20723760, PubMed:22854022, PubMed:31034892)。诱导淀粉样蛋白（如APP、HTT和SNCA）发生构象改变，驱使它们在聚集体形成之前形成紧密结构 (PubMed:20723760, PubMed:22854022, PubMed:31034892)。 {ECO:0000269|PubMed:20723760, ECO:0000269|PubMed:22854022, ECO:0000269|PubMed:31034892}。

组织特异性

Isoform Long is predominantly expressed in heart, brain and skeletal muscle. Isoform Short and Isoform Long are expressed throughout the central nervous system, including spinal cord.

亚细胞定位

Cytoplasm, cytosol