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SEPTIN9 Q9UHD8

Septin-9 (MLL septin样融合蛋白 MSF-A) (MLL septin样融合蛋白) (卵巢/乳腺septin) (Ov/Br septin) (Septin D1)

蛋白质信息 (UniProt)

Septin-9 (MLL septin样融合蛋白 MSF-A) (MLL septin样融合蛋白) (卵巢/乳腺septin) (Ov/Br septin) (Septin D1)

Q9UHD8

功能描述

形成微丝的细胞骨架GTPase (By similarity)。可能在胞质分裂中发挥作用 (Potential)。可能在2种胞内病原体,单核细胞增生李斯特菌和弗氏志贺菌的内化过程中发挥作用。 {ECO:0000250, ECO:0000305}。

组织特异性

Widely expressed. Isoforms are differentially expressed in testes, kidney, liver heart, spleen, brain, peripheral blood leukocytes, skeletal muscle and kidney. Specific isoforms appear to demonstrate tissue specificity. Isoform 5 is the most highly expressed in fetal tissue. Isoform 1 is detected in all tissues except the brain and thymus, while isoform 2, isoform 3, and isoform 4 are detected at low levels in approximately half of the fetal tissues.

亚细胞定位

Cytoplasm, cytoskeleton

关键词

3D-structure Acetylation Alternative splicing Cell cycle Cell division Chromosomal rearrangement Cytoplasm Cytoskeleton Disease variant GTP-binding