隔蛋白-8
隔蛋白-8
Q92599功能描述
形成微丝的细胞骨架GTPase (By similarity)。可能在血小板分泌中发挥作用 (PubMed:15116257)。似乎参与突触囊泡中SNARE复合物的形成过程 (By similarity)。 {ECO:0000250, ECO:0000250|UniProtKB:B0BNF1, ECO:0000269|PubMed:15116257}.; FUNCTION: [Isoform 4]: 稳定BACE1蛋白水平并促进BACE1分选和积聚至循环或内体区室，调节APP的β-淀粉样蛋白生成加工。 {ECO:0000269|PubMed:27084579}.
组织特异性
Widely expressed, including in brain, heart and platelets; most abundant in aorta. Isoform 2 is expressed at low levels in specific brain areas, such as occipital pole, frontal lobe, temporal lobe and putamen. Isoform 1 and 3 are highly expressed in specific brain areas, such as occipital pole, frontal lobe, temporal lobe and putamen. Isoform 2 is highly expressed in prostate, testis and ovary. Isoform 1 and isoform 3 are expressed at low levels in prostate, testis and ovary.
亚细胞定位
Cytoplasm
关键词