SEPTIN4 O43236

Septin-4 (Bradeion beta) (脑蛋白 H5) (CE5B3 beta) (细胞分裂控制相关蛋白 2) (hCDCREL-2) (花生样蛋白 2)

功能描述

丝状形成的细胞骨架GTPase (Probable)。促凋亡蛋白，通过与XIAP相互作用，参与肠道中LGR5阳性肠干细胞和Paneth细胞的扩增 (By similarity)。也可能在肠道细胞命运的调节中发挥作用 (By similarity)。参与造血干细胞稳态的凋亡正调节因子；通过与XIAP相互作用 (By similarity)。损伤后修复和毛囊再生的负调节因子，因其抑制毛囊干细胞增殖，可能通过与XIAP相互作用实现 (By similarity)。在雄性生育力和精子运动能力方面发挥重要作用 (PubMed:36135717)。在精子形成过程中，对于环（连接精子鞭毛中段和主段的纤维环结构）的建立至关重要，该结构是精子结构和机械完整性所必需的 (PubMed:36135717)。参与胚胎发育过程中皮层神经元的迁移和神经元前导突起的形成 (By similarity)。突触前自身受体中多巴胺能代谢所必需的；可能通过作为突触前支架蛋白的活性实现 (By similarity)。 {ECO:0000250|UniProtKB:P28661, ECO:0000269|PubMed:36135717, ECO:0000305}.; FUNCTION: [Isoform ARTS]: TGF-beta介导的细胞死亡诱导所必需的，可能也参与其他凋亡刺激诱导的细胞死亡 (PubMed:11146656, PubMed:15837787)。通过结合并抑制XIAP诱导凋亡，导致XIAP水平显著降低，进而导致caspase激活和细胞死亡 (PubMed:15029247)。介导BCL2与XIAP之间的相互作用，从而正调节BCL2的泛素化和降解并促进凋亡 (PubMed:29020630)。 {ECO:0000269|PubMed:11146656, ECO:0000269|PubMed:15029247, ECO:0000269|PubMed:15837787, ECO:0000269|PubMed:29020630}.

组织特异性

Widely expressed in adult and fetal tissues with highest expression in adult brain (at protein level), heart, liver and adrenal gland and fetal heart, kidney, liver and lung. Expressed in presynaptic terminals of dopaminergic neurons projecting from the substantia nigra pars compacta to the striatum (at protein level) (PubMed:17296554). Expressed in axonal varicosities in dopaminergic nerve terminals (at protein level) (PubMed:17296554). Expressed in the putamen and in the adjacent cerebral cortex (at protein level) (PubMed:17296554). Expressed in colonic crypts (at protein level) (PubMed:30389919). Expressed in platelets. Expressed in spermatozoa (at protein level) (PubMed:36135717).

亚细胞定位

Cytoplasm