SEMA4D Q92854

信号素-4D (A8) (BB18) (GR3) (CD抗原 CD100)

功能描述

PLXNB1和PLXNB2的细胞表面受体，在细胞-细胞信号传导中起重要作用 (PubMed:20877282)。调节GABA能突触发育 (By similarity)。以依赖PLXNB1的方式促进抑制性突触的发育 (By similarity)。通过激活PLXNB1调节海马神经元中发育中神经突的复杂性和分支，且与PLXNB1的相互作用介导RHOA的激活 (PubMed:19788569)。促进小脑颗粒细胞的迁移 (PubMed:16055703)。在免疫系统中发挥作用；诱导B细胞聚集并提高其活力 (体外) (PubMed:8876214)。通过激活PTK2B/PYK2、SRC和磷酸肌醇3-激酶-AKT通路诱导内皮细胞迁移 (PubMed:16055703)。 {ECO:0000250|UniProtKB:O09126, ECO:0000269|PubMed:16055703, ECO:0000269|PubMed:19788569, ECO:0000269|PubMed:20877282, ECO:0000269|PubMed:8876214}。

组织特异性

Strongly expressed in skeletal muscle, peripheral blood lymphocytes, spleen, and thymus and also expressed at lower levels in testes, brain, kidney, small intestine, prostate, heart, placenta, lung and pancreas, but not in colon and liver.

亚细胞定位

Cell membrane