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SDK1 Q7Z5N4

蛋白侧友-1

蛋白质信息 (UniProt)

蛋白侧友-1

Q7Z5N4

功能描述

一种黏附分子,促进视网膜内的层特异性突触连接。在特定亚型的中间神经元和视网膜神经节细胞(RGCs)中表达,并通过同嗜性相互作用促进突触连接。 {ECO:0000250|UniProtKB:Q8AV58}。

组织特异性

Up-regulated in glomeruli in HIV-associated nephropathy. In diseased glomeruli, significantly overexpressed and the expression is no longer restricted to mesangial cells but includes podocytes and parietal epithelial cells (PubMed:15213259).

亚细胞定位

Cell membrane

关键词

Alternative splicing Cell adhesion Cell membrane Disulfide bond Glycoprotein Immunoglobulin domain Membrane Proteomics identification Reference proteome Repeat