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SDCCAG8 Q86SQ7

血清学定义的结肠癌抗原8 (Antigen NY-CO-8) (中心体结肠癌自身抗原蛋白) (hCCCAP)

蛋白质信息 (UniProt)

血清学定义的结肠癌抗原8 (Antigen NY-CO-8) (中心体结肠癌自身抗原蛋白) (hCCCAP)

Q86SQ7

功能描述

在细胞极性建立和上皮管腔形成中发挥作用 (By similarity)。亦在纤毛发生及随后的Hedgehog信号通路中发挥重要作用,该通路的激活需要完整初级纤毛的存在。机制上,与RABEP2相互作用并介导其中心体定位,这对纤毛发生至关重要 (PubMed:27224062)。 {ECO:0000250|UniProtKB:Q80UF4, ECO:0000269|PubMed:27224062}。

组织特异性

Expressed in thymus, prostate, testis, ovary, small intestine, colon, mucosa, colon and renal cancer tumors.

亚细胞定位

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome

关键词

Alternative splicing Bardet-Biedl syndrome Cell junction Cell projection Ciliopathy Cilium biogenesis/degradation Coiled coil Cytoplasm Cytoskeleton Leber congenital amaurosis