分泌载体相关膜蛋白5 (分泌载体膜蛋白5) (hSCAMP5)
分泌载体相关膜蛋白5 (分泌载体膜蛋白5) (hSCAMP5)
Q8TAC9功能描述
含有信号序列的细胞因子（如CCL5）钙依赖性胞吐作用所必需。可能与SNARE机制协同作用。可能通过抑制内吞途径，在内质网应激下导致扩展的多聚谷氨酰胺(polyQ)蛋白亨廷顿蛋白(HTT)的积累中发挥作用。 {ECO:0000269|PubMed:19234194}。
组织特异性
Expressed both by neuronal and non-neuronal tissues. Expressed in brain, stomach, thyroid, spinal cord, lymph node, trachea, adrenal gland, bone marrow and in the different parts of brain. In thyroid tissues, it is expressed by the follicular epithelial cells. In the adrenal gland tissues it is detected in the zona fasciculata of the cortex region (at protein level).
亚细胞定位
Cell membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Recycling endosome membrane; Multi-pass membrane protein. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane
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