含SAM和SH3结构域蛋白1 (含脯氨酸-谷氨酸重复蛋白)
含SAM和SH3结构域蛋白1 (含脯氨酸-谷氨酸重复蛋白)
O94885功能描述
是TLR4激活下游NF-kappa-B信号传导的正调节因子。它作为支架分子组装包含TRAF6、MAP3K7、CHUK和IKBKB的分子复合物，从而促进NF-kappa-B信号传导激活 (PubMed:23776175)。调节TRAF6和MAP3K7泛素化 (PubMed:23776175)。参与细胞迁移的调节 (PubMed:23333244, PubMed:23776175, PubMed:25315659)。调节脂多糖 (LPS) 诱导的内皮细胞迁移 (PubMed:23776175)。参与皮肤色素沉着调节，通过控制表皮中黑素细胞迁移 (PubMed:23333244)。 {ECO:0000269|PubMed:23333244, ECO:0000269|PubMed:23776175, ECO:0000269|PubMed:25315659}。
组织特异性
Expressed ubiquitously, with highest levels in lung, placenta, spleen and thymus. Down-regulated in the majority (74%) of breast tumors in comparison with corresponding normal breast epithelial tissues. Expressed in the epidermis, epidermal keratinocytes, dermal fibroblasts and melanocytes (PubMed:23333244, PubMed:26203640).
亚细胞定位
Cytoplasm
关键词