含无菌α基序结构域蛋白9 (含SAM结构域蛋白9)
含无菌α基序结构域蛋白9 (含SAM结构域蛋白9)
Q5K651功能描述
功能：结合双链核酸，通过在细胞质抗病毒颗粒形成中发挥重要作用而作为抗病毒因子 (PubMed:25428864, PubMed:28157624)。可能在组织损伤的炎症反应和异位钙化的控制中发挥作用，作为TNF信号传导的下游靶点。参与EGR1的调控，与RGL2协同作用。可能参与内体融合。 {ECO:0000269|PubMed:16960814, ECO:0000269|PubMed:18094730, ECO:0000269|PubMed:21160498, ECO:0000269|PubMed:24029230, ECO:0000269|PubMed:25428864, ECO:0000269|PubMed:28157624}。
组织特异性
Widely expressed. Very low levels are detected in skeletal muscle. Not detected in brain. Down-regulated in aggressive fibromatosis, as well as in breast and colon cancers. Up-regulated in fibroblasts from patients with normophosphatemic tumoral calcinosis (NFTC).
亚细胞定位
Cytoplasm
关键词