S1PR4 O95977

1-磷酸鞘氨醇受体4 (S1P受体4) (S1P4) (内皮分化G蛋白偶联受体6) (1-磷酸鞘氨醇受体Edg-6) (S1P受体Edg-6)

功能描述

G蛋白偶联受体，在免疫细胞中高表达，调节免疫反应和细胞因子产生。作为溶血鞘脂鞘氨醇-1-磷酸 (S1P) 的受体发挥功能。结合S1P后，通过激活NRF2/PPARA信号通路，促进调节性T细胞分化并增强脂肪酸氧化 (By similarity)。还通过与FPR2及JNK信号通路的相互作用调节M1巨噬细胞活化，从而促进炎症反应 (By similarity)。此外，在炎症期间促进早期中性粒细胞动员和血管活化，促进淋巴细胞募集至引流淋巴结，并支持生发中心发育以产生有效的适应性免疫反应 (By similarity)。 {ECO:0000250|UniProtKB:Q9Z0L1, ECO:0000269|PubMed:10679247, ECO:0000269|PubMed:10753843}。

组织特异性

Specifically expressed in fetal and adult lymphoid and hematopoietic tissue as well as in lung. Considerable level of expression in adult and fetal spleen as well as adult peripheral leukocytes and lung. Lower expression in adult thymus, lymph node, bone marrow, and appendix as well as in fetal liver, thymus, and lung.

亚细胞定位

Cell membrane; Multi-pass membrane protein.