网状蛋白-3 (ASY蛋白同源物) (HAP) (神经内分泌特异性蛋白样2) (NSP样蛋白2) (神经内分泌特异性蛋白样II) (NSP样蛋白II) (NSPLII)
网状蛋白-3 (ASY蛋白同源物) (HAP) (神经内分泌特异性蛋白样2) (NSP样蛋白2) (神经内分泌特异性蛋白样II) (NSP样蛋白II) (NSPLII)
O95197功能描述
可能参与早期分泌途径中的膜运输。抑制BACE1活性和淀粉样前体蛋白加工。可能诱导caspase-8级联反应和细胞凋亡。可能在内质网应激下促进BCL2易位至线粒体。诱导内质网小管形成 (PubMed:25612671)。还作为炎症消退调节因子，通过与TRIM25和RIGI相互作用，随后削弱RIGI的'Lys-63'连接的多泛素化，导致IRF3和NF-kappa-B抑制。 {ECO:0000269|PubMed:15286784, ECO:0000269|PubMed:16054885, ECO:0000269|PubMed:17031492, ECO:0000269|PubMed:17191123, ECO:0000269|PubMed:25612671}.; FUNCTION: (Microbial infection) 在肠道病毒的病毒复制和致病机理中发挥积极作用。 {ECO:0000269|PubMed:17182608}.
组织特异性
Isoform 3 is widely expressed, with highest levels in brain, where it is enriched in neuronal cell bodies from gray matter (at protein level). Three times more abundant in macula than in peripheral retina. Isoform 1 is expressed at high levels in brain and at low levels in skeletal muscle. Isoform 2 is only found in melanoma.
亚细胞定位
Endoplasmic reticulum membrane
关键词