RP2 O75695

XRP2蛋白

功能描述

作为GTP酶激活蛋白(GAP)参与高尔基体和纤毛膜之间的运输。通过诱导GTP ARL3水解导致UNC119（或UNC119B）释放，参与蛋白质（如NPHP3）向纤毛膜的定位。与微管蛋白特异性伴侣C协同作为微管蛋白的GTP酶激活蛋白(GAP)，但不促进微管蛋白异二聚化。作为ADP核糖基化因子样蛋白的鸟嘌呤核苷酸解离抑制剂。 {ECO:0000269|PubMed:11847227, ECO:0000269|PubMed:18376416, ECO:0000269|PubMed:20106869, ECO:0000269|PubMed:22085962}。

组织特异性

Ubiquitous. Expressed in the rod and cone photoreceptors, extending from the tips of the outer segment (OS) through the inner segment (IS) and outer nuclear layer (ONL) and into the synaptic terminals of the outer plexiform layer (ONL). Also detected in the bipolar, horizontal and amacrine cells in the inner nuclear layer (INL), extending to the inner plexiform layer (IPL) and though the ganglion cell layer (GCL) and into the nerve fiber layer (NFL) (at protein level).

亚细胞定位

Cell membrane