RNLS Q5VYX0

肾酶 (EC 1.6.3.5) (单胺氧化酶-C) (MAO-C)

功能描述

催化含量较少的 1,2-dihydro-beta-NAD(P) 和 1,6-dihydro-beta-NAD(P) 氧化生成 beta-NAD(P)(+)。该酶激素由肾脏分泌，在血液中循环并调节心脏功能和全身血压。在体内通过降低心肌收缩力和心率，并防止外周血管张力的代偿性增加来降低血压，提示其与血浆儿茶酚胺增加和心血管风险升高存在因果联系。高浓度的儿茶酚胺激活血浆肾素酶并促进其分泌和合成。 {ECO:0000269|PubMed:15841207, ECO:0000269|PubMed:17385068, ECO:0000269|PubMed:25531177}。

组织特异性

Secreted into the blood by the kidney. Highly expressed in the kidney, expressed at lower level in heart, skeletal muscle and small intestine. Its plasma concentration is markedly reduced in patients with end-stage renal disease, as compared with healthy subjects.

亚细胞定位

Secreted