RNFT1 Q5M7Z0

E3泛素蛋白连接酶RNFT1 (EC 2.3.2.27) (蛋白PTD016) (环指和跨膜结构域包含蛋白1)

功能描述

E3泛素-蛋白连接酶，作用于内质网(ER)相关降解(ERAD)途径，该途径靶向在内质网(ER)中积累的错误折叠蛋白进行泛素化及随后的蛋白酶体介导的降解。保护细胞免受内质网应激诱导的细胞凋亡。 {ECO:0000269|PubMed:27485036}。

组织特异性

Expressed at highest levels in testis, lower levels in heart, liver, lung, and kidney (PubMed:17074343). Not detected in brain, ovary, and uterus (PubMed:17074343). Down-regulated in testis from patients with maturation arrest (MA) or Sertoli cell-only syndrome (SCOS) (PubMed:17074343). Ubiquitously expressed with high expression in testis (PubMed:27485036).

亚细胞定位

Endoplasmic reticulum membrane