RNF6 Q9Y252

E3泛素蛋白连接酶RNF6 (EC 2.3.2.27)

功能描述

E3泛素-protein连接酶，介导LIMK1的'Lys-48'连接的多泛素化及其随后的靶向proteasome降解 (By similarity)。通过调节LIMK1的周转负向调节轴突生长 (By similarity)。介导AR/雄激素受体的'Lys-6'和'Lys-27'连接的多泛素化，从而调节其转录活性 (PubMed:19345326)。也可能结合DNA并作为转录调节因子发挥作用 (By similarity)。在巨噬细胞中介导QKI的多泛素化，导致其降解 (By similarity)。 {ECO:0000250|UniProtKB:Q9DBU5, ECO:0000269|PubMed:19345326}。

组织特异性

Weakly expressed in peripheral blood, spleen, prostate, testis and ovary (PubMed:19345326). According to a report, it is preferentially expressed in testis and ovary and hardly detected in other tissues (PubMed:18368307).

亚细胞定位

Nucleus