E3泛素蛋白连接酶RNF43 (EC 2.3.2.27) (环指蛋白43) (RING型E3泛素转移酶RNF43)
E3泛素蛋白连接酶RNF43 (EC 2.3.2.27) (环指蛋白43) (RING型E3泛素转移酶RNF43)
Q68DV7功能描述
E3 ubiquitin-protein ligase，作为Wnt信号通路的负调控因子，通过介导Wnt受体复合物组分Frizzled的泛素化、内吞及随后的降解发挥作用。作用于典型和非典型Wnt信号通路 (PubMed:18313049, PubMed:22575959, PubMed:22895187)。与RSPO2和ZNRF3一起，构成控制肢体特化的主开关 (By similarity)。 {ECO:0000250|UniProtKB:P0DPR2, ECO:0000269|PubMed:18313049, ECO:0000269|PubMed:22575959, ECO:0000269|PubMed:22895187}。
组织特异性
Expressed in fetal kidney, fetal lung, in colon cancer tissues, hepatocellular carcinomas and lung adenocarcinomas. Overexpressed in colorectal cancer cell lines.
亚细胞定位
Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Nucleus envelope. Note=According to a report, may be secreted.
关键词