RNF182 Q8N6D2

E3泛素蛋白连接酶RNF182 (EC 2.3.2.27) (环指蛋白182) (RING型E3泛素转移酶RNF182)

功能描述

E3泛素-蛋白连接酶，介导ATP6V0C的泛素化并通过泛素-蛋白酶体途径靶向其降解 (PubMed:18298843)。亦通过介导NF-kappa-B组分RELA的“Lys”-48连接泛素化及随后的降解，在抑制TLR触发的先天免疫反应中发挥作用 (PubMed:31432514)。 {ECO:0000269|PubMed:18298843, ECO:0000269|PubMed:31432514}。

组织特异性

Up-regulated in neuronal cells subjected to cell death-inducing injuries, such as oxygen and glucose deprivation (at protein level). Could be up-regulated in Alzheimer disease brains (PubMed:18298843). Highly expressed in innate immune organs such as lymph nodes and spleen and in immune cells such as macrophages and dendritic cells (PubMed:31432514).

亚细胞定位

Membrane