RNF181 Q9P0P0

E3泛素蛋白连接酶RNF181 (EC 2.3.2.27) (环指蛋白181)

功能描述

E3 ubiquitin-protein ligase，以硫酯的形式从E2 ubiquitin-conjugating enzyme接受ubiquitin，然后直接将ubiquitin转移至靶底物 (PubMed:18331836)。催化26S proteasome亚基PSMC2/RPT1的单泛素化 (PubMed:24811749)。 {ECO:0000269|PubMed:18331836, ECO:0000269|PubMed:24811749}。

组织特异性

Widely expressed, with highest levels in liver and heart and lowest levels in brain and skeletal muscle. Expressed in platelets (at protein level).