RNF11 Q9Y3C5

环指蛋白 11

功能描述

泛素编辑蛋白复合物的必需组分，该复合物还包含TNFAIP3、ITCH和TAX1BP1，确保炎症信号通路的瞬时特性。促进TNF刺激后TNFAIP3与RIPK1的结合。TNFAIP3去泛素化RIPK1上的'Lys-63'多聚泛素链，并催化'Lys-48'-多聚泛素链的形成。这导致RIPK1被蛋白酶体降解，从而终止TNF或LPS介导的NF-kappa-B活化。将STAMBP募集至E3泛素连接酶SMURF2进行泛素化，导致其被26S蛋白酶体降解。 {ECO:0000269|PubMed:14755250}。

组织特异性

Expressed at low levels in the lung, liver, kidney, pancreas, spleen, prostate, thymus, ovary, small intestine, colon, and peripheral blood lymphocytes, and, at intermediate levels, in the testis, heart, brain and placenta. Highest expression in the skeletal muscle. In the brain, expressed at different levels in several regions: high levels in the amygdala, moderate in the hippocampus and thalamus, low in the caudate and extremely low levels in the corpus callosum (at protein level). Restricted to neurons, enriched in somatodendritic compartments and excluded from white matter (at protein level). In substantia nigra, present in cell bodies and processes of dopaminergic and nondopaminergic cells (at protein level). In Parkinson disease, sequestered in Lewy bodies and neurites. Overexpressed in breast cancer cells, but not detected in the surrounding stroma and weakly, if at all, in normal breast epithelial cells (at protein level). Also expressed in several tumor cell lines.

亚细胞定位

Early endosome. Recycling endosome. Cytoplasm. Nucleus. Note=Predominantly cytoplasmic, when unphosphorylated, and nuclear, when phosphorylated by PKB/AKT1.