RIPOR2 Q9Y4F9

Rho家族相互作用细胞极化调节因子2

功能描述

作为小GTPase RHOA的抑制剂，在调节成肌细胞和毛细胞分化、淋巴细胞T增殖以及中性粒细胞极化中发挥多种作用 (PubMed:17150207, PubMed:23241886, PubMed:24687993, PubMed:24958875, PubMed:25588844, PubMed:27556504)。抑制趋化因子诱导的T淋巴细胞反应，如细胞粘附、极化和迁移 (PubMed:23241886)。也参与中性粒细胞极化、趋化和粘附的调节 (By similarity)。为内耳耳蜗内毛细胞和外毛细胞静纤毛的正常发育所必需 (By similarity)。在维持静纤毛基底域的结构组织中发挥作用 (By similarity)。参与机械感觉毛细胞的功能 (By similarity)。为正常听力所必需 (PubMed:24958875)。 {ECO:0000250|UniProtKB:Q80U16, ECO:0000269|PubMed:17150207, ECO:0000269|PubMed:23241886, ECO:0000269|PubMed:24687993, ECO:0000269|PubMed:24958875, ECO:0000269|PubMed:27556504}.; FUNCTION: [Isoform 2]: 作为小GTPase RHOA的抑制剂 (PubMed:25588844)。通过促进丝状伪足和肌管的形成，在胎儿单核成肌细胞分化中发挥作用 (PubMed:17150207)。维持初始T淋巴细胞处于静息状态 (PubMed:27556504)。 {ECO:0000269|PubMed:17150207, ECO:0000269|PubMed:25588844, ECO:0000269|PubMed:27556504}.

组织特异性

Expressed in primary fetal mononuclear myoblast (PubMed:17150207). Expressed strongly in naive T lymphocytes (PubMed:27556504). Expressed weakly in activated T lymphocytes (at protein level) (PubMed:27556504). Expressed in blood cells and adult tissues of hematopoietic origin, such as the secondary lymphoid organs (PubMed:23241886). Expressed in cytotrophoblast (PubMed:9055809).

亚细胞定位

Cytoplasm