RIC-3蛋白 (抗胆碱酯酶抑制剂蛋白3)
RIC-3蛋白 (抗胆碱酯酶抑制剂蛋白3)
Q7Z5B4功能描述
分子伴侣，促进alpha-7 (CHRNA7)和alpha-8 (CHRNA8)烟碱型乙酰胆碱受体的正确亚基组装和表面运输 (PubMed:12821669, PubMed:15504725, PubMed:16120769, PubMed:18691158, PubMed:32204458)。也可能促进同源血清素能5-HT3受体，以及异源乙酰胆碱受体alpha-3/beta-2、alpha-3/beta-4、alpha-4/beta-2和alpha-4/beta-4的功能性表达。 {ECO:0000269|PubMed:12821669, ECO:0000269|PubMed:15504725, ECO:0000269|PubMed:15809299, ECO:0000269|PubMed:15927954, ECO:0000269|PubMed:16120769, ECO:0000269|PubMed:17609200, ECO:0000269|PubMed:18691158, ECO:0000269|PubMed:32204458}。
组织特异性
Broadly expressed, with high levels in muscle, brain, heart, pancreas and testis. In the central nervous system, highest levels are detected in the cerebellum and pituitary gland. Over-expressed in brains from patients with bipolar disease or schizophrenia. Isoform 5 is predominantly expressed in the brain.
亚细胞定位
[Isoform 1]: Endoplasmic reticulum membrane; Single-pass membrane protein.; SUBCELLULAR LOCATION: [Isoform 2]: Endoplasmic reticulum membrane; Single-pass membrane protein. Golgi apparatus membrane; Single-pass membrane protein.
关键词