RHO P08100

视紫红质 (Opsin-2)

蛋白质信息 (UniProt)

视紫红质 (Opsin-2)

P08100

功能描述

低光强度下成像视觉所需的感光受体 (PubMed:7846071, PubMed:8107847)。出生后感光细胞存活所必需 (PubMed:12566452, PubMed:2215617)。发色团11-顺式视黄醛光诱导异构化为全反式视黄醛引发构象变化，从而通过G-proteins激活信号传导 (PubMed:26200343, PubMed:28524165, PubMed:28753425, PubMed:8107847)。随后的受体磷酸化介导抑制蛋白SAG置换结合的G-protein alpha亚基并终止信号传导 (PubMed:26200343, PubMed:28524165)。 {ECO:0000269|PubMed:12566452, ECO:0000269|PubMed:2215617, ECO:0000269|PubMed:26200343, ECO:0000269|PubMed:28753425, ECO:0000269|PubMed:7846071, ECO:0000269|PubMed:8107847, ECO:0000305|PubMed:28524165}。

组织特异性

Rod shaped photoreceptor cells which mediate vision in dim light.

亚细胞定位

Membrane

关键词

3D-structure Acetylation Cell projection Chromophore Congenital stationary night blindness Disease variant Disulfide bond G-protein coupled receptor Glycoprotein Lipoprotein

外部链接

UniProt: P08100

NCBI Gene

GeneCards