RGS9 O75916

G蛋白信号调节因子9 (RGS9)

功能描述

通过增加G蛋白α亚基的GTPase活性从而使其转变为非活性的GDP结合形式，进而抑制信号转导。结合GNAT1。参与光转导；是视觉转导恢复期的关键元件（通过相似性）。{ECO:0000250}。

组织特异性

Highly expressed in the caudate and putamen, lower levels found in the hypothalamus and nucleus accumbens and very low levels in cerebellum. Not expressed in globus pallidus or cingulate cortex. Isoform 2 is expressed predominantly in pineal gland and retina. Isoform 3 is expressed in retina (abundant in photoreceptors).

亚细胞定位

[Isoform 3]: Membrane; Peripheral membrane protein. Note=Isoform 3 is targeted to the membrane via its interaction with RGS9BP.