G蛋白信号调节因子20 (RGS20) (Gz选择性GTP酶激活蛋白) (G(z)GAP) (Gz-GAP) (G蛋白信号调节因子Z1) (Gz选择性蛋白信号调节因子1)
G蛋白信号调节因子20 (RGS20) (Gz选择性GTP酶激活蛋白) (G(z)GAP) (Gz-GAP) (G蛋白信号调节因子Z1) (Gz选择性蛋白信号调节因子1)
O76081功能描述
通过增加G蛋白α亚基的GTPase活性从而抑制信号转导，进而驱动其进入非活性的GDP结合形式。选择性结合G(z)-alpha和G(alpha)-i2亚基，加速其GTPase活性并调节其信号活动。G(z)-alpha的活性受G-protein的磷酸化和棕榈酰化抑制。负向调节mu-opioid受体介导的G-proteins激活 (By similarity)。 {ECO:0000250, ECO:0000269|PubMed:12379657}。
组织特异性
Isoform 5 is expressed in brain at high levels in the caudate nucleus and temporal lobe.
亚细胞定位
Membrane; Lipid-anchor. Nucleus. Cytoplasm. Note=Shuttles between the cytoplasm/cell membrane and the nucleus. Anchored to the membrane through palmitoylation.
关键词