RBPMS Q93062

具有多重剪接的RNA结合蛋白 (RBP-MS) (RBPMS) (心脏和RRM表达序列) (Hermes)

功能描述

[Isoform A]: RNA结合蛋白，介导pre-mRNA可变剪接(AS)的调控 (PubMed:24860013, PubMed:26347403)。作为特定pre-mRNA靶标剪接事件的激活因子(FLNB, HSPG2, LIPA1, MYOCD, PTPRF和PPFIBP1)或抑制因子(TPM1, ACTN1, ITGA7, PIEZO1, LSM14B, MBNL1和MBML2)发挥作用 (By similarity)。与RNA结合蛋白RBFOX2和MBNL1/2一起，通过调节涉及肌动蛋白细胞骨架和粘着斑机制的众多pre-mRNA的AS，激活与分化型收缩性血管平滑肌细胞(SMC)相关的剪接程序，提示其在促进细胞分化状态中的作用 (By similarity)。结合与串联CAC三核苷酸基序相关的内含子、外显子和3'-UTR，这些基序由可变间隔区隔开，至少以二聚体形式结合。RBPMS结合串联CAC基序所需的最小RNA长度为15 nt，间距范围为1至9 nt。也能结合CA二核苷酸重复序列 (PubMed:24860013, PubMed:26347403)。通过结合侧翼内含子区域的CAC串联重复序列介导TPM1外显子3的抑制，随后进行高级寡聚化并与包括MBNL1和RBFOX2在内的其他剪接调节因子进行异型相互作用，从而阻止ATP依赖性剪接复合物的组装 (By similarity)。 {ECO:0000250|UniProtKB:A0A8I6G705, ECO:0000269|PubMed:24860013, ECO:0000269|PubMed:26347403}.; FUNCTION: [Isoform C]: 作为pre-mRNA可变剪接(AS)的调节因子发挥作用 (By similarity)。结合mRNA (PubMed:17099224)。调节ACTN1、FLNB的AS，尽管效率低于isoform A / RBPMSA (By similarity)。以TGFB1依赖性方式作为SMAD转录活性的共激活因子，可能通过增加C端SSXS区域SMAD2和SMAD3的磷酸化并促进SMAD蛋白的核积累来实现 (PubMed:17099224)。 {ECO:0000250|UniProtKB:A0A8I6G705, ECO:0000269|PubMed:17099224}.

组织特异性

Ubiquitously expressed, at various levels depending on the isoform and the tissue (PubMed:8855282). Strongly expressed in the heart, prostate, small intestine, large intestine, and ovary; moderately expressed in the placenta, lung, liver, kidney, pancreas, and testis; and poorly expressed in the skeletal muscle, spleen, thymus and peripheral leukocytes (PubMed:8855282).

亚细胞定位

Nucleus