RASSF10 A6NK89

含Ras结合域蛋白10

功能描述

在调节胚胎神经发生中发挥重要作用。 {ECO:0000250|UniProtKB:Q8BL43}。

组织特异性

Expressed in brain. Tends to be down-regulated in astrocytic gliomas due to promoter methylation. Methylation occurs early in gliomagenesis and the extent of methylation parallels with higher glioma grades, so that methylation is observed in close to 70% WHO grade IV primary glioblastomas, but not in grade I astrocytomas.

亚细胞定位

Cytoplasm, cytosol