含Ras关联结构域蛋白1
含Ras关联结构域蛋白1
Q9NS23功能描述
潜在的肿瘤抑制因子。死亡受体依赖性凋亡所必需。通过阻止STK3/MST2和STK4/MST1的去磷酸化，介导Fas诱导的凋亡过程中STK3/MST2和STK4/MST1的激活。当与MOAP1结合时，促进BAX构象改变并在TNF和TNFSF10刺激下易位至线粒体膜。Isoform A与CDC20（后期促进复合物APC的激活因子）相互作用，导致APC活性和有丝分裂进程受抑制。通过调节cyclin D1蛋白的积累，在G1/S期转换水平负向调节细胞周期进程，从而抑制增殖。Isoform C已被证实不执行这些功能，尚未发现该亚型的功能。Isoform A破坏MDM2、DAXX和USP7之间的相互作用，从而在DNA损伤应答的细胞周期检查点控制中，通过促进MDM2自身泛素化，有助于TP53的有效激活。 {ECO:0000269|PubMed:10888881, ECO:0000269|PubMed:11333291, ECO:0000269|PubMed:12024041, ECO:0000269|PubMed:14743218, ECO:0000269|PubMed:15109305, ECO:0000269|PubMed:15949439, ECO:0000269|PubMed:16510573, ECO:0000269|PubMed:18566590, ECO:0000269|PubMed:21199877}。
组织特异性
Isoform A and isoform C are ubiquitously expressed in all tissues tested, however isoform A is absent in many corresponding cancer cell lines. Isoform B is mainly expressed in hematopoietic cells.
亚细胞定位
[Isoform A]: Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Nucleus. Note=Localizes to cytoplasmic microtubules during interphase, to bipolar centrosomes associated with microtubules during prophase, to spindle fibers and spindle poles at metaphase and anaphase, to the midzone during early telophase, and to the midbody in late telophase in cells. Colocalizes with MDM2 in the nucleus.; SUBCELLULAR LOCATION: [Isoform C]: Nucleus. Note=Predominantly nuclear.
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