RASA1 P20936

Ras GTP酶激活蛋白1 (GAP) (GTP酶激活蛋白) (RasGAP) (Ras p21蛋白激活剂) (p120GAP)

蛋白质信息 (UniProt)

Ras GTP酶激活蛋白1 (GAP) (GTP酶激活蛋白) (RasGAP) (Ras p21蛋白激活剂) (p120GAP)

P20936

功能描述

GTPase激活蛋白 (GAP)，刺激Ras蛋白（如NRAS）的内在GTPase活性，促进其从活性GTP结合状态转变为非活性GDP结合状态，从而终止Ras信号传导。 {ECO:0000269|PubMed:11389730, ECO:0000269|PubMed:2123878, ECO:0000269|PubMed:3201259, ECO:0000269|PubMed:8360177}。

组织特异性

In placental villi, detected only in the trophoblast layer (cytotrophoblast and syncytiotrophoblast). Not detected in stromal, endothelial or Hofbauer cells (at protein level).

亚细胞定位

Cytoplasm

关键词

3D-structure Acetylation Alternative splicing Cytoplasm Direct protein sequencing Disease variant GTPase activation Phosphoprotein Proteomics identification Reference proteome

外部链接

UniProt: P20936

NCBI Gene

GeneCards