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RAPGEF6 Q8TEU7

Rap鸟苷酸交换因子6 (含PDZ结构域鸟苷酸交换因子2) (PDZ-GEF2) (RA-GEF-2)

蛋白质信息 (UniProt)

Rap鸟苷酸交换因子6 (含PDZ结构域鸟苷酸交换因子2) (PDZ-GEF2) (RA-GEF-2)

Q8TEU7

功能描述

Rap1A、Rap2A和M-Ras GTPases的鸟嘌呤核苷酸交换因子(GEF)。不与cAMP相互作用。{ECO:0000269|PubMed:11524421, ECO:0000269|PubMed:12581858}。

组织特异性

Isoform 3 has highest expression levels in the brain, heart, liver, lung and placenta and is barely detectable in skeletal muscle, kidney and pancreas.

亚细胞定位

Cytoplasm

关键词

3D-structure Acetylation Alternative splicing Cell membrane Cytoplasm Guanine-nucleotide releasing factor Membrane Phosphoprotein Proteomics identification Reference proteome