RANGRF Q9HD47

Ran鸟嘌呤核苷酸释放因子 (RanGNRF) (Ran结合蛋白MOG1)

蛋白质信息 (UniProt)

Ran鸟嘌呤核苷酸释放因子 (RanGNRF) (Ran结合蛋白MOG1)

Q9HD47

功能描述

可能调节RAN的细胞内运输 (PubMed:11290418)。促进RAN的鸟嘌呤核苷酸释放，并通过阻止RAN鸟嘌呤核苷酸交换因子RCC1的结合来抑制新GTP的结合 (PubMed:29040603)。调节细胞核内GTP结合型RAN的水平，从而在RAN依赖性有丝分裂纺锤体动力学的调节中发挥作用 (PubMed:29040603)。增强心肌细胞细胞膜上SCN5A的表达 (PubMed:18184654, PubMed:21621375, PubMed:23420830)。 {ECO:0000269|PubMed:11290418, ECO:0000269|PubMed:18184654, ECO:0000269|PubMed:21621375, ECO:0000269|PubMed:23420830, ECO:0000269|PubMed:29040603}。

组织特异性

Isoform 1 and isoform 2 are ubiquitously expressed (PubMed:11290418). Detected in heart and brain (PubMed:21621375).

亚细胞定位

Nucleus

关键词

3D-structure Alternative splicing Cell membrane Cytoplasm Guanine-nucleotide releasing factor Membrane Nucleus Protein transport Proteomics identification Reference proteome

外部链接

UniProt: Q9HD47

NCBI Gene

GeneCards