Ran结合蛋白9 (RanBP9) (BPM-L) (BPM90) (Ran结合蛋白M) (RanBPM) (RanBP7)
Ran结合蛋白9 (RanBP9) (BPM-L) (BPM90) (Ran结合蛋白M) (RanBPM) (RanBP7)
Q96S59功能描述
可能作为支架蛋白，以及作为接头蛋白将膜受体偶联到细胞内信号通路 (Probable)。作为细胞铺展和肌动蛋白细胞骨架重排的介导因子 (PubMed:18710924)。CTLH E3泛素-蛋白连接酶复合物的核心组分，该复合物选择性接受来自UBE2H的泛素，并介导转录因子HBP1的泛素化及随后的蛋白酶体降解 (PubMed:29911972)。可能参与ITGB2/LFA-1和其他整合素的信号传导 (PubMed:14722085)。通过招募Sos并激活Ras通路来增强HGF-MET信号传导 (PubMed:12147692)。增强二氢睾酮诱导的AR反式激活活性，以及地塞米松诱导的NR3C1反式激活活性，但不影响雌激素诱导的反式激活 (PubMed:12361945, PubMed:18222118)。稳定TP73亚型Alpha，可能是通过抑制其泛素化，并增加其促凋亡活性 (PubMed:15558019)。抑制DYRK1A和DYRK1B的激酶活性。抑制FMR1与RNA结合。 {ECO:0000269|PubMed:12147692, ECO:0000269|PubMed:12361945, ECO:0000269|PubMed:14500717, ECO:0000269|PubMed:14722085, ECO:0000269|PubMed:15381419, ECO:0000269|PubMed:15558019, ECO:0000269|PubMed:18222118, ECO:0000269|PubMed:18710924, ECO:0000269|PubMed:29911972, ECO:0000305}。
组织特异性
Ubiquitously expressed, with highest levels in testes, placenta, heart, and muscle, and lowest levels in lung. Within the brain, expressed predominantly by neurons in the gray matter of cortex, the granular layer of cerebellum and the Purkinje cells.
亚细胞定位
Cytoplasm
关键词