RAET1G Q6H3X3

UL-16结合蛋白5 (视黄酸早期转录本1G蛋白)

功能描述

[Isoform 1]: 结合并激活KLRK1/NKG2D受体，介导自然杀伤细胞细胞毒性。 {ECO:0000269|PubMed:15240696, ECO:0000269|PubMed:18544572, ECO:0000269|PubMed:19658097}.; FUNCTION: [Isoform 3]: 下调KLRK1的表达并刺激自然杀伤细胞分泌IFNG。 {ECO:0000269|PubMed:18544572}.; FUNCTION: [Isoform 2]: 刺激自然杀伤细胞分泌IFNG。 {ECO:0000269|PubMed:18544572}.

组织特异性

Isoform 1 is highly expressed in colon and in a number of tumor cell lines and highly restricted in normal tissues. Both isoforms are frequently expressed in cell lines derived from epithelial cancers, and in primary breast cancers.

亚细胞定位

[Isoform 1]: Cell membrane