细胞周期检查点蛋白RAD17 (hRad17) (RF-C/激活因子1同源物)
细胞周期检查点蛋白RAD17 (hRad17) (RF-C/激活因子1同源物)
O75943功能描述
对于持续的细胞生长、染色体稳定性维持以及DNA损伤后ATR依赖性检查点激活至关重要 (PubMed:10208430, PubMed:11418864, PubMed:11687627, PubMed:11799063, PubMed:12672690, PubMed:14624239, PubMed:15235112)。具有微弱的ATP酶活性，该活性是其结合染色质所必需的 (PubMed:10208430, PubMed:11418864, PubMed:11687627, PubMed:11799063, PubMed:12672690, PubMed:14624239, PubMed:15235112)。参与将9-1-1 (RAD1-RAD9-HUS1)复合物和RHNO1招募至染色质，并参与CHEK1激活 (PubMed:21659603)。通过介导MRN复合物招募至DNA损伤位点参与同源重组 (PubMed:24534091)。可能还作为DNA复制进程的传感器 (PubMed:12578958, PubMed:14500819, PubMed:15538388)。 {ECO:0000269|PubMed:10208430, ECO:0000269|PubMed:11418864, ECO:0000269|PubMed:11687627, ECO:0000269|PubMed:11799063, ECO:0000269|PubMed:12578958, ECO:0000269|PubMed:12672690, ECO:0000269|PubMed:14500819, ECO:0000269|PubMed:14624239, ECO:0000269|PubMed:15235112, ECO:0000269|PubMed:15538388, ECO:0000269|PubMed:21659603, ECO:0000269|PubMed:24534091}。
组织特异性
Overexpressed in various cancer cell lines and in colon carcinoma (at protein level). Isoform 2 and isoform 3 are the most abundant isoforms in non irradiated cells (at protein level). Ubiquitous at low levels. Highly expressed in testis, where it is expressed within the germinal epithelium of the seminiferous tubuli. Weakly expressed in seminomas (testicular tumors).
亚细胞定位
Nucleus
关键词