RAB25 P57735

Ras相关蛋白Rab-25 (EC 3.6.5.2) (CATX-8)

功能描述

小GTP酶Rab是细胞内膜运输的关键调节因子，从运输囊泡的形成到其与膜的融合。Rab在非活性的GDP结合形式和活性的GTP结合形式之间循环，后者能够招募不同的下游效应因子至膜上，这些效应因子直接负责囊泡的形成、运动、系留和融合 (By similarity)。RAB25调节上皮细胞的分化、增殖和存活，从而在肿瘤发生中发挥关键作用 (PubMed:17925226)。促进细胞的侵袭性迁移，其功能在于将整合素alpha-V/beta-1定位并维持在延伸伪足的尖端 (PubMed:17925226)。通过控制CLDN4在紧密连接处的表达和定位，参与上皮形态发生的调节 (By similarity)。可能选择性调节顶端循环途径 (By similarity)。与MYO5B共同调节跨细胞运输 (By similarity)。 {ECO:0000250|UniProtKB:E2RQ15, ECO:0000250|UniProtKB:P46629, ECO:0000250|UniProtKB:P61106, ECO:0000250|UniProtKB:Q9WTL2, ECO:0000269|PubMed:17925226}。

组织特异性

Expression is restricted to epithelial cells (PubMed:15502842). Expressed in ovarian epithelium (NOE) and breast tissue. Expressed in ovarian cancer; expression is increased relative to NOE cells. Expression in ovarian cancer is stage dependent, with stage III and stage IV showing higher levels than early stage cancers. Expressed in breast cancer; expression is increased relative to normal breast tissue.

亚细胞定位

Cell membrane