含Pyrin和HIN结构域蛋白1 (干扰素诱导蛋白X)
含Pyrin和HIN结构域蛋白1 (干扰素诱导蛋白X)
Q6K0P9功能描述
乳腺癌细胞中IFN肿瘤抑制活性的主要介导因子。促进MDM2的泛素化及随后的降解，从而导致p53/TP53稳定。促进HDAC1的泛素化及随后的降解，进而增强maspin表达，并损害癌细胞的侵袭活性。 {ECO:0000269|PubMed:16479015, ECO:0000269|PubMed:18247378}。
组织特异性
Expressed in spleen, lymph node and peripheral blood leukocytes, and at lower levels in thymus, bone marrow and fetal liver. Down-regulated in breast tumors.
亚细胞定位
[Isoform 1]: Nucleus, nucleoplasm.; SUBCELLULAR LOCATION: [Isoform 3]: Nucleus, nucleoplasm.; SUBCELLULAR LOCATION: [Isoform 5]: Nucleus. Nucleus speckle.
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