PVRIG Q6DKI7

跨膜蛋白 PVRIG (CD112受体) (CD112R) (含脊髓灰质炎病毒受体相关免疫球蛋白结构域蛋白)

功能描述

NECTIN2的细胞表面受体。可能作为共抑制受体，抑制T细胞受体介导的信号。与NECTIN2相互作用后，抑制T细胞增殖。与CD226竞争结合NECTIN2。 {ECO:0000269|PubMed:26755705}。

组织特异性

Expressed in some types of immune cells. Expressed at low levels on the surface of freshly isolated T-cells and natural killer (NK) cells, predominantly on CD8+ T-cells (mainly memory/effector, but not naive cells) and on both CD16+ and CD16- NK cells. T-cell expression levels are variable among individuals. Not detected in B-cells, naive or helper T-cells, monocytes, nor neutrophils (at protein level). Not detected in dendritic cells.

亚细胞定位

Cell membrane