前列腺素D2受体2 (表达于Th2细胞的趋化因子受体同源分子) (G蛋白偶联受体44) (CD抗原CD294)
前列腺素D2受体2 (表达于Th2细胞的趋化因子受体同源分子) (G蛋白偶联受体44) (CD抗原CD294)
Q9Y5Y4功能描述
前列腺素D2 (PGD2)的受体。偶联G(i)-蛋白。受体激活可能导致百日咳毒素敏感的cAMP水平降低和Ca(2+)动员。PI3K信号通路也参与介导PTGDR2的效应。PGD2诱导受体内在化。CRTH2内在化可受多种激酶调节，如PKC、PKA、GRK2、GPRK5/GRK5和GRK6。受体激活至少部分负责免疫调节和过敏/炎症反应。 {ECO:0000269|PubMed:11208866, ECO:0000269|PubMed:11535533, ECO:0000269|PubMed:17196174}.
组织特异性
Widespread expression. High expression in stomach, small intestine, heart and thymus. Intermediate expression in colon, spinal cord and peripheral blood and low expression in brain, skeletal muscle and spleen. Expressed also on Th2- and Tc2- type cells, eosinophils and basophils.
亚细胞定位
Cell membrane
关键词