PSCA O43653

前列腺干细胞抗原

功能描述

可能参与细胞增殖的调控。在体外具有抑制细胞增殖的活性。 {ECO:0000269|PubMed:18488030}.; FUNCTION: 可能作为烟碱型乙酰胆碱受体 (nAChRs) 活性的调节因子。在体外抑制烟碱诱导的信号传导，可能涉及含有alpha-3:beta-2或alpha-7的nAChRs。 {ECO:0000305|PubMed:25680266}.

组织特异性

Highly expressed in prostate (basal, secretory and neuroendocrine epithelium cells). Also found in bladder (transitional epithelium), placenta (trophoblasts), stomach (neuroendocrine cells), colon (neuroendocrine cells) and kidney (collecting ducts). Overexpressed in prostate cancers and expression is correlated with tumor stage, grade and androgen-independence. Highly expressed in prostate cancer bone metastases. Expressed in gastric epithelial cells, mainly in the isthmus (at protein level). Not detected in normal intestinal epithelium (at protein level). Expressed in brain cortex; expression is significantly increased in the front cortex of Alzheimer disease patients.

亚细胞定位

Cell membrane